The Revelation icon (96.5 × 75.4 cm), a work dated around the middle of the 18th century, is kept in the monastery of Preveli, Rethymno. This important heirloom, attributed to the painter Michaēl Prevelēs, is one of the few surviving works depicting the Revelation on Crete. In the introductory part of the paper the evolution of the iconographic theme of the Revelation during the post-Byzantine period is presented, in order to showcase the historical and ideological background of the era and the scarcity of the theme. The following part includes a brief description of the icon. In the third part an iconographic analysis of the theme is attempted by comparing the scenes with respective examples from the Orthodox iconography and the Western art, revealing possible iconographic patterns used by the painter. The last part summarizes relevant iconographic observations and an attempt is made to trace the possible routes of the diffusion of the iconographic patterns. For this purpose, the painter’s relations with important art centers of the era in the Ottoman-occupied Greece and the West are examined. Finally, the association of the Preveli monastery with individuals who could influence circulation of the iconographic patterns is presented.