The church of St Panteleimon is located close to the village of Bizariano(n), perhaps in order to house the existing agiasma. Resent restoration work allows us to assume that the original church was a cross-in-square with a dome, built in the mid-11th century. Around the end of the 12th century it was rebuilt as a three-aisle vaulted basilica, after a collapse. At the end of the Venetian era the upper parts of the church and the row of piers were reconstructed.

The interior was decorated three times, as the fragments indicate. To the first layer (second half of 11th century) belongs the depiction of Saint Nicholas, on the south wall, which is connected with the painting tradition of Constantinople. The slender figures of Ss Arsenios and Efthymios on the south wall and St John the Baptist with his hands in supplication correspond to the high quality of the late Comnenian tradition at the end of the 12th century. The bishops and the Melismos, the Community of the Apostles, the enthroned Madonna with two Archangels on the niche of the apse, the breast-feeding St Anne, the whole body of saints, George, Theodore Stratelates, Michael, Demetrios, George Diasorites on the south wall and the archangels Michael and Gabriel on the west, are dated in the first half of the 13th century. To the same layer, which represents the conservative and renewing trends that predominate in general this period, belong the depictions of Christ and St Panteleimon on the eastern piers, as part of the iconostasis.

The great significance of the church is obvious as far as the architecture and its alterations are concerned, which contribute to the deeper understanding of external influences and local processes. Furthermore, the three layers of frescos represent the predominant trends of high-quality painting from the Middle Byzantine period to the early Venetian era.